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Effect of 5 years of imaging and CEA follow-up to detect recurrence of colorectal cancer: The FFCD PRODIGE 13 randomised phase III trial

Published:April 28, 2015DOI:https://doi.org/10.1016/j.dld.2015.03.021
      Colorectal cancer (CRC), the most common digestive cancer in France, is a major public health problem. There are an estimated 40,000 new cases every year and 200,000 prevalent cases [
      • Chauvenet M.
      • Lepage C.
      • Jooste V.
      • et al.
      Prevalence of patients with colorectal cancer requiring follow-up or active treatment.
      ]. Its incidence has increased by more than 50% over the past 20 years (24,000 new cases/year in 1980, 36,600 in 2000). On the other hand, over the same period, the number of deaths has remained stable (16,000 deaths in 2000), which reflects a major therapeutic progress [
      • Faivre-Finn C.
      • Bouvier-Benhamiche A.M.
      • Phelip J.M.
      • et al.
      Colon cancer in France: evidence for improvement in management and survival.
      ,
      • Finn-Faivre C.
      • Maurel J.
      • Benhamiche A.M.
      • et al.
      Evidence of improving survival of patients with rectal cancer in France: a population based study.
      ].
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