Abstract
Background
Coeliac disease is a chronic enteropathy characterized by an increased mortality caused
by its complications, mainly refractory coeliac disease, small bowel carcinoma and
abdominal lymphoma. Aim of the study was to study the epidemiology of complications
in patients with coeliac disease.
Methods
Retrospective multicenter case–control study based on collection of clinical and laboratory
data. The incidence of complicated coeliac disease was studied among coeliac patients
directly diagnosed in four Italian centres. Patients referred to these centres after
a diagnosis of coeliac disease and/or complicated coeliac disease in other hospitals
were therefore excluded.
Results
Between 1/1999 and 10/2011, 1840 adult coeliac patients were followed up for 7364.3
person-years. Fourteen developed complications. Since five patients died, at the end
of the observation period (10/2011), the prevalence of complicated coeliac disease
was 9/1835 (1/204, 0.49%, 95% CI 0.2–0.9%). The annual incidence of complicated coeliac
disease in the study period was 14/7364 (0.2%, 95% CI 0.1–0.31%). Although complications
tend to occur soon after the diagnosis of coeliac disease, Kaplan–Meier curve analysis
showed that they can actually occur at any time after the diagnosis of coeliac disease.
Conclusions
Complications of coeliac disease in our cohort were quite rare, though characterised
by a very high mortality.
Keywords
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Article info
Publication history
Published online: November 21, 2013
Accepted:
October 15,
2013
Received:
May 21,
2013
Footnotes
☆This project was supported by a grant from the Fondazione Celiachia “Studio di possibili fattori ambientali e sviluppo di nuove strategie terapeutiche nelle complicanze della malattia celiaca”. The funding source had no role.
Identification
Copyright
© 2013 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Inc. All rights reserved.
