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Prevalence and clinical significance of pancreatic cysts associated with cysts in other organs

      Abstract

      Background and aim

      Von Hippel-Lindau disease is associated with serous cysts in the pancreas and kidneys. In this study we determined the prevalence of pancreatic cysts occurring concurrently with other abdominal cysts and tested the hypothesis that these patients might represent a forme fruste of Von Hippel-Lindau disease and be more likely to be serous cysts.

      Methods

      A retrospective chart review of patients undergoing endoscopic ultrasound of pancreatic cysts.

      Results

      A total of 156 patients were included in the study. Eighty-five patients (54.8%) had cyst(s) in the pancreas and at least one other intra-abdominal cyst. These cysts included 24 (27.9%) serous cysts, 30 (34.9%), mucinous cysts, 6 (7%) adenocarcinoma and 25 (29.4%) unknowns. Seventy-one patients (45.2%) had isolated pancreatic cysts. These included 17 (23.9%) serous cysts, 28 (39.5%) mucinous cysts, 4 (5.6%) adenocarcinoma and 22 (31%) unknowns. The odds of serous cysts with concurrent extra-pancreatic and pancreatic cysts compared to odds of serous cysts with pancreatic cysts alone were 1.3 (95% CI: 0.6–2.9).

      Conclusions

      Pancreatic cysts are associated with cysts in other abdominal organs in 54.8% patients. The prevalence of serous cysts was not higher amongst individuals with multiple organ cysts compared to those with only pancreatic cysts.

      Abbreviations:

      CEA (carcinoembryonic antigen), CI (confidence interval), CT (computerized tomography), EUS (endoscopic ultrasound), FNA (fine needle aspiration), IPMN (intrapapillary mucinous neoplasm), MCN (mucinous cystic neoplasm), MRI (magnetic resonance imaging), MRCP (magnetic resonance cholangiopancreatography), SCA (serous cystadenoma), VHL (Von Hippel-Lindau disease)

      Keywords

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