Abstract
In patients with Crohn’s disease, the prevalence of gallstones is increased, especially
in patients with ileal disease or after ileal resection. Recent studies point to alterations
in enterohepatic bilirubin cycling, resulting in increased biliary bilirubin levels
leading to pigment rather than cholesterol gallstones. Gallbladder (hypo)motility
is another important factor in the pathogenesis of gallstones leading to bile stasis,
crystallisation and stone formation. Postprandial gallbladder emptying is not markedly
reduced in patients with Crohn’s disease but lower fasting gallbladder volumes have
been observed in patients with colonic disease or after ileocaecal resection. Prolonged
and repeated bowel rest before and after intestinal surgery has been recognised as
a significant risk factor for gallstone formation in patients with Crohn’s disease.
Keywords
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References
- Gallstones in patients with disorders of the terminal ileum and disturbed bile salt metabolism.Br Med J. 1969; 3: 494-496
- Liver disease and gallstones in regional enteritis.Gastroenterology. 1971; 60: 237-245
- Gallstones in inflammatory bowel disease.Am J Dig Dis. 1974; 19: 109-112
- Gallstones after ileostomy and ileal resection.Gut. 1975; 16: 932-936
- Ultrasound survey of gallstones and other hepatobiliary disorders in patients with Crohn’s disease.Dig Dis Sci. 1984; 29: 930-933
- Cholelithiasis and urolithiasis in Crohn’s disease.Scand J Gastroenterol. 1987; 22: 253-256
- Cholelithiasis in inflammatory bowel disease.Dis Colon Rectum. 1990; 33: 791-794
- Gallstones in Crohn’s disease.Hepatogastroenterology. 1990; 37: 83-84
- Pathogenesis of gall stones in Crohn’s disease: An alternative explanation.Gut. 1994; 35: 94-97
- The prevalence of gallstone disease in a defined cohort of patients with Crohn’s disease.Am J Gastroenterol. 1999; 94: 1261-1266
- Gallstones: pathogenesis.Lancet. 1991; 338: 1117-1121
- Lithogenic bile in patients with ileal dysfunction.Gut. 1972; 13: 415-420
- Effects of ileal resection on biliary lipids and bile acid composition in patients with Crohn’s disease.Gut. 1991; 32: 1488-1491
- Bile composition in patients with ileal resection due to Crohn’s disease.Inflamm Bowel Dis. 1998; 4: 89-94
- Enterohepatic cycling of bilirubin: a putative mechanism for pigment gallstone formation in ileal Crohn’s disease.Gastroenterology. 1999; 116: 1420-1427
- Human gallbladder mucine accelerates nucleation of cholesterol in artificial bile.Gastroenterology. 1984; 87: 270-275
- Impaired fatty-meal-stimulated gallbladder contractility in patients with Crohn’s disease.Clin Sci. 1992; 83: 689-693
- Gallbladder hypokinesia in Crohn’s disease.Digestion. 1997; 58: 458-463
- No evidence for abnormal gallbladder emptying in Crohn’s disease.Hepatogastroenterology. 1996; 43: 807-812
- Gallbladder motility in Crohn disease: influence of disease localization and bowel resection.Scand J Gastroenterol. 2000; 35: 1157-1162
- Effects of colectomy on gallbladder motility in patients with ulcerative colitis.Dig Dis Sci. 1997; 42: 259-264
- Plasma cholecystokinin levels and gallbladder volumes after proctocolectomy with ileal pouch-anal anastomosis.Surgery. 1995; 117: 705-711
- Effect of loxiglumide and atropine on erythromycine-induced reduction in gallbladder volume in human subjects.Hepatology. 1992; 16: 937-942
- Cholinergic effects on gallbladder emptying in humans.Gastroenterology. 1985; 89: 716-722
- Disturbed autonomic nerve function in patients with Crohn’s disease.Scand J Gastroenterol. 1991; 26: 361-366
- Motor cycles with phase III in antrum are associated with high motilin levels and prolonged gallbladder emptying.Am J Physiol. 1993; 264: G569-600
- Gastrointestinal motility disorders in patients with inactive Crohn’s Disease.Scand J Gastroenterol. 1997; 82: 1107-1117
- Gall bladder sludge formation during prolonged fasting after gastrointestinal tract surgery.Gut. 1985; 26: 734-738
- Gallbladder disease in patients on long-term parenteral nutrition.Gastroenterology. 1983; 84: 148-154
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© 2003 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Inc. All rights reserved.
