Digestive and Liver Disease
Volume 44, Issue 4 , Pages 303-310 , April 2012

Metabolomic profiling of 17 bile acids in serum from patients with primary biliary cirrhosis and primary sclerosing cholangitis: A pilot study

  • Jocelyn Trottier

      Affiliations

    • Laboratory of Molecular Pharmacology, CHUQ Research Center and the Faculty of Pharmacy, Laval University, Québec, Canada
    • ,
  • Andrzej Białek

      Affiliations

    • Department of Gastroenterology, Pomeranian Medical University, Szczecin, Poland
    • ,
  • Patrick Caron

      Affiliations

    • Laboratory of Molecular Pharmacology, CHUQ Research Center and the Faculty of Pharmacy, Laval University, Québec, Canada
    • ,
  • Robert J. Straka

      Affiliations

    • Experimental and Clinical Pharmacology Department, College of Pharmacy, University of Minnesota, Minneapolis, USA
    • ,
  • Jenny Heathcote

      Affiliations

    • Toronto Western Hospital, University Health Network, Toronto, Canada
    • ,
  • Piotr Milkiewicz

      Affiliations

    • Liver Unit and Liver Research Laboratories, Pomeranian Medical University, Szczecin, Poland
    • ,
  • Olivier Barbier

      Affiliations

    • Laboratory of Molecular Pharmacology, CHUQ Research Center and the Faculty of Pharmacy, Laval University, Québec, Canada
    • Corresponding Author InformationCorresponding author at: Laboratory of Molecular Pharmacology, CHUQ Research Center, 2705 Laurier Boulevard, Québec (QUE), G1V 4G2 Canada. Tel.: +1 418 654 2296; fax: +1 418 654 2761.

Received 2 March 2011 ,Accepted 30 October 2011.

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☆ Grant support: This study was supported by grants from the Canadian Institute of Health Research (CIHR; grant #MOP-84338) and the Canadian Foundation for Innovation (CFI, grant #10469). J. Trottier is holder of a scholarship from CIHR. O. Barbier is holder of a salary grant from CIHR (New investigator award #MSH95330) and the “Fonds pour la Recherche en Santé du Québec, FRSQ” (junior II award). The GOLDN study was supported by the NIH Heart, Lung and Blood Institute Grant U 01 HL72524, Genetic and Environmental Determinants of Triglycerides.

PII: S1590-8658(11)00425-7

doi: 10.1016/j.dld.2011.10.025

Digestive and Liver Disease
Volume 44, Issue 4 , Pages 303-310 , April 2012

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