Association of SLCO1B1*1b with peptic ulcer amongst Japanese patients taking low-dose aspirin

Abstract 

Background

In the recent case–control study, we showed an inverse association between peptic ulcer and angiotensin type 1 receptor (AT1R) blockers (ARBs) or HMG-Co A reductase inhibitors (statins). The aim was to evaluate whether the genotypes of uptake and efflux transporters of ARBs and statins relate to the presence of peptic ulcer and/or ulcer bleeding associated with aspirin use.

Methods

Patients taking 100mg of enteric-coated aspirin for cardiovascular diseases who also participated in endoscopic surveillance were studied. SLCO1B, ABCC2, ABCG2, and MDR1 genotypes were determined by PCR or PCR-RFLP.

Results

492 patients enrolled including 78 with peptic ulcer. The frequencies of the SLCO1B1 521TT genotype were significantly higher in the ulcer group (p=0.006) compared to the controls. After adjustment for significant factors, the SLCO1B1 *1b haplotype was significantly associated with peptic ulcer (OR, 3.64; 95% CI, 1.81–7.29).

Conclusions

SLCO1B1*1b haplotype may identify patients at increased risk for aspirin-induced peptic ulcer.

Keywords: Angiotensin type 1 receptor blockers, Clinical pharmacology, HMG-Co A reductase inhibitors