Health-related quality of life is impaired in active collagenous colitis

Hjortswang, Henrik; Tysk, Curt; Bohr, Johan; Benoni, Cecilia; Vigren, Lina; Kilander, Anders; Larsson, Lasse; Taha, Yesuf; Ström, Magnus

doi:10.1016/j.dld.2010.06.004

« Previous Next »Digestive and Liver Disease
Volume 43, Issue 2 , Pages 102-109, February 2011

Health-related quality of life is impaired in active collagenous colitis

Henrik Hjortswang
- Department of Gastroenterology and Endocrinology, Division of Gastroenterology and Hepatology, Linköping University Hospital, Faculty of Health Sciences, Linköping University, Sweden
- Swedish Organization for the study of Inflammatory Bowel Disease (SOIBD), a national organization for gastroenterologists, colorectal surgeons and basic scientists.
- Corresponding author. Fax: +46 13 223506.
Curt Tysk
- Division of Gastroenterology, Department of Medicine, Örebro University Hospital, School of Health and Medical Sciences, Örebro University, Örebro, Sweden
- Swedish Organization for the study of Inflammatory Bowel Disease (SOIBD), a national organization for gastroenterologists, colorectal surgeons and basic scientists.
Johan Bohr
- Division of Gastroenterology, Department of Medicine, Örebro University Hospital, School of Health and Medical Sciences, Örebro University, Örebro, Sweden
- Swedish Organization for the study of Inflammatory Bowel Disease (SOIBD), a national organization for gastroenterologists, colorectal surgeons and basic scientists.
Cecilia Benoni
- Division of Gastroenterology, Department of Medicine, MAS University Hospital, Malmö, Sweden
- Swedish Organization for the study of Inflammatory Bowel Disease (SOIBD), a national organization for gastroenterologists, colorectal surgeons and basic scientists.
Lina Vigren
- Division of Gastroenterology, Department of Medicine, MAS University Hospital, Malmö, Sweden
Anders Kilander
- Division of Gastroenterology, Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
- Swedish Organization for the study of Inflammatory Bowel Disease (SOIBD), a national organization for gastroenterologists, colorectal surgeons and basic scientists.
Lasse Larsson
- Division of Gastroenterology, Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
Yesuf Taha
- Department of Gastroenterology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
Magnus Ström
- Department of Gastroenterology and Endocrinology, Division of Gastroenterology and Hepatology, Linköping University Hospital, Faculty of Health Sciences, Linköping University, Sweden
- Swedish Organization for the study of Inflammatory Bowel Disease (SOIBD), a national organization for gastroenterologists, colorectal surgeons and basic scientists.

Received 13 January 2010; accepted 1 June 2010. published online 20 July 2010.

Abstract

Objectives

The characteristic clinical symptoms of collagenous colitis are non-bloody diarrhoea, urgency and abdominal pain. Treatment is aimed at reducing the symptom burden and the disease impact on patients’ health-related quality of life. The objective of this study was to analyse health-related quality of life in patients with collagenous colitis.

Methods

In a cross-sectional, postal HRQL survey, 116 patients with collagenous colitis at four Swedish hospitals completed four health-related quality of life questionnaires, two disease-specific (Inflammatory Bowel Disease Questionnaire and Rating Form of IBD Patient Concerns), and two generic (Short Form 36, SF-36, and Psychological General Well-Being, PGWB), and a one-week symptom diary. Demographic and disease-related data were collected. Results for the collagenous colitis population were compared with a background population controlled for age and gender (n=8931).

Results

Compared with a Swedish background population, patients with collagenous colitis scored significantly worse in all Short Form 36 dimensions (p<0.01), except physical function. Patients with active disease scored worse health-related quality of life than patients in remission. Co-existing disease had an impact on health-related quality of life measured with the generic measures. Lower education level and shorter disease duration were associated with decreased well-being.

Conclusion

Health-related quality of life was impaired in patients with collagenous colitis compared with a background population. Disease activity is the most important factor associated with impairment of health-related quality of life. Patients in remission have a health-related quality of life similar to a background population.

Keywords: Collagenous colitis, Health, Health-related quality of life, Inflammatory bowel disease (IBD), Microscopic colitis, Quality of life

Abbreviations: CC, collagenous colitis, HRQOL, health-related quality of life, IBD, inflammatory bowel disease, IBDQ, Inflammatory Bowel Disease Questionnaire, PGWB, Psychological General Well-Being, RFIPC, Rating Form of IBD Patient Concerns, SF-36, Short Form-36, UC, ulcerative colitis