Health-related quality of life is impaired in active collagenous colitis
Received 13 January 2010; accepted 1 June 2010. published online 20 July 2010. Corrected Proof
Abstract
Objectives
The characteristic clinical symptoms of collagenous colitis are non-bloody diarrhoea, urgency and abdominal pain. Treatment is aimed at reducing the symptom burden and the disease impact on patients’ health-related quality of life. The objective of this study was to analyse health-related quality of life in patients with collagenous colitis.
Methods
In a cross-sectional, postal HRQL survey, 116 patients with collagenous colitis at four Swedish hospitals completed four health-related quality of life questionnaires, two disease-specific (Inflammatory Bowel Disease Questionnaire and Rating Form of IBD Patient Concerns), and two generic (Short Form 36, SF-36, and Psychological General Well-Being, PGWB), and a one-week symptom diary. Demographic and disease-related data were collected. Results for the collagenous colitis population were compared with a background population controlled for age and gender (n=8931).
Results
Compared with a Swedish background population, patients with collagenous colitis scored significantly worse in all Short Form 36 dimensions (p<0.01), except physical function. Patients with active disease scored worse health-related quality of life than patients in remission. Co-existing disease had an impact on health-related quality of life measured with the generic measures. Lower education level and shorter disease duration were associated with decreased well-being.
Conclusion
Health-related quality of life was impaired in patients with collagenous colitis compared with a background population. Disease activity is the most important factor associated with impairment of health-related quality of life. Patients in remission have a health-related quality of life similar to a background population.
aDepartment of Gastroenterology and Endocrinology, Division of Gastroenterology and Hepatology, Linköping University Hospital, Faculty of Health Sciences, Linköping University, Sweden
bDivision of Gastroenterology, Department of Medicine, Örebro University Hospital, School of Health and Medical Sciences, Örebro University, Örebro, Sweden
cDivision of Gastroenterology, Department of Medicine, MAS University Hospital, Malmö, Sweden
dDivision of Gastroenterology, Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
eDepartment of Gastroenterology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
Corresponding author. Fax: +46 13 223506.
1 Swedish Organization for the study of Inflammatory Bowel Disease (SOIBD), a national organization for gastroenterologists, colorectal surgeons and basic scientists.
ABSTRACT
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