Digestive and Liver Disease
Volume 42, Issue 10 , Pages 667-674 , October 2010

Diagnostic value and clinical utility of contrast enhanced ultrasound in intestinal diseases

  • Barbara Braden

      Affiliations

    • Translational Gastroenterology Unit, John Radcliffe Hospital, Oxford, UK
    • Corresponding Author InformationCorresponding author. Tel.: +44 1865 228760; fax: +44 1865 228561.
  • ,
  • Andre Ignee

      Affiliations

    • Medical and Imaging Department, Caritas - Krankenhaus, Bad Mergentheim, Germany
  • ,
  • Michael Hocke

      Affiliations

    • Medical and Imaging Department, Caritas - Krankenhaus, Bad Mergentheim, Germany
    • Klinikum Meiningen, Meiningen, Germany
  • ,
  • Rebecca M. Palmer

      Affiliations

    • Translational Gastroenterology Unit, John Radcliffe Hospital, Oxford, UK
  • ,
  • Christoph Dietrich

      Affiliations

    • Medical and Imaging Department, Caritas - Krankenhaus, Bad Mergentheim, Germany

Received 1 January 2010 ,Accepted 26 May 2010.

References 

  1. Hirche TO, Russler J, Schroder O, et al. The value of routinely performed ultrasonography in patients with Crohn disease. Scand J Gastroenterol. 2002;37:1178–1183
  2. Parente F, Greco S, Molteni M, et al. Imaging inflammatory bowel disease using bowel ultrasound. Eur J Gastroenterol Hepatol. 2005;17:283–291
  3. Esteban JM, Maldonado L, Sanchiz V, et al. Activity of Crohn's disease assessed by colour Doppler ultrasound analysis of the affected loops. Eur Radiol. 2001;11:1423–1428
  4. Spalinger J, Patriquin H, Miron MC, et al. Doppler US in patients with Crohn disease: vessel density in the diseased bowel reflects disease activity. Radiology. 2000;217:787–791
  5. Rapaccini GL, Pompili M, Orefice R, et al. Contrast-enhanced power Doppler of the intestinal wall in the evaluation of patients with Crohn disease. Scand J Gastroenterol. 2004;39:188–194
  6. Gorce JM, Arditi M, Schneider M. Influence of bubble size distribution on the echogenicity of ultrasound contrast agents: a study of SonoVue. Invest Radiol. 2000;35:661–671
  7. Greis C. Technology overview: SonoVue (Bracco, Milan). Eur Radiol. 2004;14(Suppl. 8):P11–15
  8. Kersting S, Konopke R, Kersting F, et al. Quantitative perfusion analysis of transabdominal contrast-enhanced ultrasonography of pancreatic masses and carcinomas. Gastroenterology. 2009;137:1903–1911
  9. Calabrese E, La Seta F, Buccellato A, et al. Crohn's disease: a comparative prospective study of transabdominal ultrasonography, small intestine contrast ultrasonography, and small bowel enema. Inflamm Bowel Dis. 2005;11:139–145
  10. Dietrich CF, Jedrzejczyk M, Ignee A. Sonographic assessment of splanchnic arteries and the bowel wall. Eur J Radiol. 2007;64:202–212
  11. Ludwig D, Wiener S, Bruning A, et al. Mesenteric blood flow is related to disease activity and risk of relapse in ulcerative colitis: a prospective follow up study. Gut. 1999;45:546–552
  12. Ludwig D, Wiener S, Bruning A, et al. Mesenteric blood flow is related to disease activity and risk of relapse in Crohn's disease: a prospective follow-up study. Am J Gastroenterol. 1999;94:2942–2950
  13. Homann N, Klarmann U, Fellermann K, et al. Mesenteric pulsatility index analysis predicts response to azathioprine in patients with Crohn's disease. Inflamm Bowel Dis. 2005;11:126–132
  14. Ignee A, Jedrejczyk M, Schuessler G, et al. Quantitative contrast enhanced ultrasound of the liver for time intensity curves—reliability and potential sources of errors. Eur J Radiol. 2009;
  15. Pauls S, Gabelmann A, Schmidt SA, et al. Evaluating bowel wall vascularity in Crohn's disease: a comparison of dynamic MRI and wideband harmonic imaging contrast-enhanced low MI ultrasound. Eur Radiol. 2006;16:2410–2417
  16. Di Sabatino A, Fulle I, Ciccocioppo R, et al. Doppler enhancement after intravenous Levovist injection in Crohn's disease. Inflamm Bowel Dis. 2002;8:251–257
  17. Girlich C, Jung EM, Iesalnieks I, et al. Quantitative assessment of bowel wall vascularisation in Crohn's disease with contrast-enhanced ultrasound and perfusion analysis. Clin Hemorheol Microcirc. 2009;43:141–148
  18. Kratzer W, Schmidt SA, Mittrach C, et al. Contrast-enhanced wideband harmonic imaging ultrasound (SonoVue): a new technique for quantifying bowel wall vascularity in Crohn's disease. Scand J Gastroenterol. 2005;40:985–991
  19. Schreyer AG, Finkenzeller T, Gossmann H, et al. Microcirculation and perfusion with contrast enhanced ultrasound (CEUS) in Crohn's disease: first results with linear contrast harmonic imaging (CHI). Clin Hemorheol Microcirc. 2008;40:143–155
  20. De Pascale A, Garofalo G, Perna M, et al. Contrast-enhanced ultrasonography in Crohn's disease. Radiol Med. 2006;111:539–550
  21. Robotti D, Cammarota T, Debani P, et al. Activity of Crohn disease: value of Color-Power-Doppler and contrast-enhanced ultrasonography. Abdom Imaging. 2004;29:648–652
  22. Plikat K, Klebl F, Buchner C, et al. Evaluation of intestinal hyperaemia in inflamed bowel by high resolution Contrast Harmonic Imaging (CHI). Ultraschall Med. 2004;25:257–262
  23. Migaleddu V, Scanu AM, Quaia E, et al. Contrast-enhanced ultrasonographic evaluation of inflammatory activity in Crohn's disease. Gastroenterology. 2009;137:43–52
  24. Serra C, Menozzi G, Labate AM, et al. Ultrasound assessment of vascularization of the thickened terminal ileum wall in Crohn's disease patients using a low-mechanical index real-time scanning technique with a second generation ultrasound contrast agent. Eur J Radiol. 2007;62:114–121
  25. Ripolles T, Martinez MJ, Paredes JM, et al. Crohn disease: correlation of findings at contrast-enhanced US with severity at endoscopy. Radiology. 2009;253:241–248
  26. Kunihiro K, Hata J, Manabe N, et al. Predicting the need for surgery in Crohn's disease with contrast harmonic ultrasound. Scand J Gastroenterol. 2007;42:577–585
  27. Guidi L, De Franco A, De Vitis I, et al. Contrast-enhanced ultrasonography with SonoVue after infliximab therapy in Crohn's disease. Eur Rev Med Pharmacol Sci. 2006;10:23–26
  28. Quaia E, Migaleddu V, Baratella E, et al. The diagnostic value of small bowel wall vascularity after sulfur hexafluoride-filled microbubble injection in patients with Crohn's disease. Correlation with the therapeutic effectiveness of specific anti-inflammatory treatment. Eur J Radiol. 2009;69:438–444
  29. Esteban JM, Aleixandre A, Hurtado MJ, et al. Contrast-enhanced power Doppler ultrasound in the diagnosis and follow-up of inflammatory abdominal masses in Crohn's disease. Eur J Gastroenterol Hepatol. 2003;15:253–259
  30. Sallomi DF. The use of contrast-enhanced power Doppler ultrasound in the diagnosis and follow-up of inflammatory abdominal masses associated with Crohn's disease. Eur J Gastroenterol Hepatol. 2003;15:249–251
  31. Volkmer BG, Nesslauer T, Kufer R, et al. Diagnosis of vesico-intestinal fistulas by contrast medium enhanced 3-D ultrasound. Ultraschall Med. 2001;22:81–86
  32. Maconi G, Carsana L, Fociani P, et al. Small bowel stenosis in Crohn's disease: clinical, biochemical and ultrasonographic evaluation of histological features. Aliment Pharmacol Ther. 2003;18:749–756
  33. Maconi G, Greco S, Duca P, et al. Prevalence and clinical significance of sonographic evidence of mesenteric fat alterations in Crohn's disease. Inflamm Bowel Dis. 2008;14:1555–1561
  34. Kratzer W, von Tirpitz C, Mason R, et al. Contrast-enhanced power Doppler sonography of the intestinal wall in the differentiation of hypervascularized and hypovascularized intestinal obstructions in patients with Crohn's disease. J Ultrasound Med. 2002;21:149–157quiz 158–149
  35. Schlottmann K, Kratzer W, Scholmerich J. Doppler ultrasound and intravenous contrast agents in gastrointestinal tract disorders: current role and future implications. Eur J Gastroenterol Hepatol. 2005;17:263–275
  36. Yamaguchi T, Yoshida S, Tanaka S, et al. Predicting the clinical response to cytapheresis in steroid-refractory or -dependent ulcerative colitis using contrast-enhanced ultrasonography. Scand J Gastroenterol. 2009;44:831–837
  37. Kessler N, Cyteval C, Gallix B, et al. Appendicitis: evaluation of sensitivity, specificity, and predictive values of US, Doppler US, and laboratory findings. Radiology. 2004;230:472–478
  38. Je BK, Kim SB, Lee SH, et al. Diagnostic value of maximal-outer-diameter and maximal-mural-thickness in use of ultrasound for acute appendicitis in children. World J Gastroenterol. 2009;15:2900–2903
  39. Gaitini D, Beck-Razi N, Mor-Yosef D, et al. Diagnosing acute appendicitis in adults: accuracy of color Doppler sonography and MDCT compared with surgery and clinical follow-up. Am J Roentgenol. 2008;190:1300–1306
  40. Catalano O, Nunziata A, Sandomenico F, et al. Acute flank pain: comparison of unenhanced helical CT and ultrasonography in detecting causes other than ureterolithiasis. Emerg Radiol. 2002;9:146–154
  41. Patriquin HB, Garcier JM, Lafortune M, et al. Appendicitis in children and young adults: Doppler sonographic–pathologic correlation. Am J Roentgenol. 1996;166:629–633
  42. Incesu L, Yazicioglu AK, Selcuk MB, et al. Contrast-enhanced power Doppler US in the diagnosis of acute appendicitis. Eur J Radiol. 2004;50:201–209
  43. Lameris W, van Randen A, Bipat S, et al. Graded compression ultrasonography and computed tomography in acute colonic diverticulitis: meta-analysis of test accuracy. Eur Radiol. 2008;18:2498–2511
  44. Gorg C, Egbring J, Bert T. Contrast-enhanced ultrasound of epiploic appendagitis. Ultraschall Med. 2009;30:163–167
  45. Dietrich CF, Lembcke B, Seifert H, et al. Ultrasound diagnosis of penicillin-induced segmental hemorrhagic colitis. Dtsch Med Wochenschr. 2000;125:755–760
  46. Ludolph T, Schmidt-Wilcke HA. Ultrasound diagnosis of pseudomembranous colitis. Dtsch Med Wochenschr. 2000;125:750–754
  47. Gorschluter M, Glasmacher A, Hahn C, et al. Severe abdominal infections in neutropenic patients. Cancer Invest. 2001;19:669–677
  48. Downey DB, Wilson SR. Pseudomembranous colitis: sonographic features. Radiology. 1991;180:61–64
  49. Dietrich CF, Hermann S, Klein S, et al. Sonographic signs of neutropenic enterocolitis. World J Gastroenterol. 2006;12:1397–1402
  50. Klein SA, Martin H, Schreiber-Dietrich D, et al. A new approach to evaluating intestinal acute graft-versus-host disease by transabdominal sonography and colour Doppler imaging. Br J Haematol. 2001;115:929–934
  51. Stranzinger E, Dipietro MA, Yarram S, et al. Intramural and subserosal echogenic foci on US in large-bowel intussusceptions: prognostic indicator for reducibility?. Pediatr Radiol. 2009;39:42–46
  52. Hanquinet S, Anooshiravani M, Vunda A, et al. Reliability of color Doppler and power Doppler sonography in the evaluation of intussuscepted bowel viability. Pediatr Surg Int. 1998;13:360–362
  53. Kong MS, Wong HF, Lin SL, et al. Factors related to detection of blood flow by color Doppler ultrasonography in intussusception. J Ultrasound Med. 1997;16:141–144
  54. Hamada T, Yamauchi M, Tanaka M, et al. Prospective evaluation of contrast-enhanced ultrasonography with advanced dynamic flow for the diagnosis of intestinal ischaemia. Br J Radiol. 2007;80:603–608
  55. Hata J, Kamada T, Haruma K, et al. Evaluation of bowel ischemia with contrast-enhanced US: initial experience. Radiology. 2005;236:712–715
  56. Drelich-Zbroja A, Jargiello T, Szymanska A, et al. The diagnostic value of Levovist in Doppler imaging of visceral arteries in patients with abdominal angina before and after angioplasty. Eur J Ultrasound. 2003;16:225–235
  57. Fukuta N, Kitano M, Maekawa K, et al. Estimation of the malignant potential of gastrointestinal stromal tumors: the value of contrast-enhanced coded phase-inversion harmonics US. J Gastroenterol. 2005;40:247–255
  58. Lassau N, Chami L, Benatsou B, et al. Dynamic contrast-enhanced ultrasonography (DCE-US) with quantification of tumor perfusion: a new diagnostic tool to evaluate the early effects of antiangiogenic treatment. Eur Radiol. 2007;17(Suppl. 6):F89–98
  59. Lassau N, Lamuraglia M, Chami L, et al. Gastrointestinal stromal tumors treated with imatinib: monitoring response with contrast-enhanced sonography. Am J Roentgenol. 2006;187:1267–1273
  60. Fraquelli M, Sarno A, Girelli C, et al. Reproducibility of bowel ultrasonography in the evaluation of Crohn's disease. Dig Liver Dis. 2008;40:860–866
  61. Romanini L, Passamonti M, Aiani L, et al. Economic assessment of contrast-enhanced ultrasonography for evaluation of focal liver lesions: a multicentre Italian experience. Eur Radiol. 2007;17(Suppl. 6):F99–F106
  62. Faccioli N, D’Onofrio M, Comai A, et al. Contrast-enhanced ultrasonography in the characterization of benign focal liver lesions: activity-based cost analysis. Radiol Med. 2007;112:810–820
  63. Nurnberg D, Jung A, Schmieder C, et al. What's the price of routine sonography—results of an analysis of costs and processes in a district hospital. Ultraschall Med. 2008;29:405–417
  64. Giesel FL, Delorme S, Sibbel R, et al. Contrast-enhanced ultrasound for the characterization of incidental liver lesions—an economical evaluation in comparison with multi-phase computed tomography. Ultraschall Med. 2009;30:259–268
  65. Schuler A, Reuss J, Delorme S, et al. Costs of clinical ultrasound examinations—an economical cost calculation and analysis. Ultraschall Med. 2010 Feb 24 [Epub ahead of print].

PII: S1590-8658(10)00200-8

doi: 10.1016/j.dld.2010.05.018

Digestive and Liver Disease
Volume 42, Issue 10 , Pages 667-674 , October 2010