Digestive and Liver Disease
Volume 43, Issue 2 , Pages 143-146 , February 2011

Relationship between portal chronic inflammation and disease severity in paediatric non-alcoholic fatty liver disease

  • Anna Alisi

      Affiliations

    • Liver Unit, Pediatric Hospital “Bambino Gesù”, IRCCS, Rome, Italy
    • These authors contributed equally to this work.
  • ,
  • Giorgio Bedogni

      Affiliations

    • Clinical Epidemiology Unit, Liver Research Center, Basovizza, Trieste, Italy
    • Department of Maternal and Pediatric Sciences, University of Milan, Fondazione IRCCS Cà Granda - Ospedale Maggiore Policlinico, Milan, Italy
    • These authors contributed equally to this work.
  • ,
  • Rita De Vito

      Affiliations

    • Laboratory of Pathology, Pediatric Hospital “Bambino Gesù”, IRCCS, Rome, Italy
  • ,
  • Donatella Comparcola

      Affiliations

    • Liver Unit, Pediatric Hospital “Bambino Gesù”, IRCCS, Rome, Italy
  • ,
  • Melania Manco

      Affiliations

    • Scientific Directorate, Pediatric Hospital “Bambino Gesù”, IRCCS, Rome, Italy
  • ,
  • Valerio Nobili

      Affiliations

    • Liver Unit, Pediatric Hospital “Bambino Gesù”, IRCCS, Rome, Italy
    • Corresponding Author InformationCorresponding author at: Liver Unit, Pediatric Hospital “Bambino Gesù”, Via S. Onofrio 4, 00165 Rome, Italy. Tel.: +39 06 68 59 22 43; fax: +39 06 68 59 21 92.

Received 18 January 2010 ,Accepted 8 May 2010.

References 

  1. Dunn W, Schwimmer JB. The obesity epidemic and nonalcoholic fatty liver disease in children. Curr Gastroenterol Rep. 2008;10:67–72
  2. Alisi A, Manco M, Vania A, et al. Pediatric nonalcoholic fatty liver disease in 2009. J Pediatr. 2009;155:469–474
  3. Feldstein AE, Charatcharoenwitthaya P, Treeprasertsuk S, et al. The natural history of non-alcoholic fatty liver disease in children: a follow-up study for up to 20 years. Gut. 2009;58:1538–1544
  4. Nobili V, Marcellini M, De Vito R, et al. NAFLD in children: a prospective clinical-pathological study and effect of lifestyle advice. Hepatology. 2006;44:458–465
  5. Schwimmer JB, Behling C, Newbury R, et al. Histopathology of pediatric nonalcoholic fatty liver disease. Hepatology. 2005;42:641–649
  6. Brunt EM, Kleiner DE, Wilson LA, et al. Portal chronic inflammation in nonalcoholic fatty liver disease (NAFLD): a histologic marker of advanced NAFLD-clinicopathologic correlations from the nonalcoholic steatohepatitis clinical research network. Hepatology. 2009;49:809–820
  7. Hübscher SG. Histological assessment of non-alcoholic fatty liver disease. Histopathology. 2006;49:450–465
  8. Nobili V, Bedogni G, Alisi A, et al. A protective effect of breastfeeding on the progression of non-alcoholic fatty liver disease. Arch Dis Child. 2009;94:801–805
  9. Manco M, Bedogni G, Monti L, et al. Intima-media thickness and liver histology in obese children and adolescents with non-alcoholic fatty liver disease. Atherosclerosis. 2010;209:463–468
  10. Nobili V, Alisi A, Vania A, et al. The pediatric NAFLD fibrosis index: a predictor of liver fibrosis in children with non-alcoholic fatty liver disease. BMC Med. 2009;7:21
  11. Manco M, Bedogni G, Marcellini M, et al. Waist circumference correlates with liver fibrosis in children with non-alcoholic steatohepatitis. Gut. 2008;57:1283–1287
  12. Lohman TG, Roche AF, Martorell R. Anthropometric standardization reference manual. Champaign, IL: Human Kinetics Books; 1988;
  13. Kuczmarski RJ, Ogden CL, Grummer-Strawn LM, et al. CDC growth charts: United States. Adv Data. 2000;314:1–27
  14. Wallace TM, Levy JC, Matthews DR. Use and abuse of HOMA modeling. Diabetes Care. 2004;27:1487–1495
  15. Matsuda M, DeFronzo RA. Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care. 1999;22:1462–1470
  16. National High Blood Pressure Education Program Working Group on High Blood Pressure. The Fourth Report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics 2004;114.
  17. Kleiner DE, Brunt EM, Van Natta M, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology. 2005;41:1313–1321
  18. Ananth CV, Kleinbaum DG. Regression models for ordinal responses: a review of methods and applications. Int J Epidemiol. 1997;26:1323–1333
  19. Hilbe J. Logistic regression models. Boca Raton: CRC Press; 2009;

PII: S1590-8658(10)00171-4

doi: 10.1016/j.dld.2010.05.007

Digestive and Liver Disease
Volume 43, Issue 2 , Pages 143-146 , February 2011