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Digestive and Liver Disease
Volume 42, Issue 12
, Pages 902-907
, December 2010
Lamivudine-resistance mutations can be selected even at very low levels of hepatitis B viraemia
References
- . Antiviral resistance and hepatitis B therapy. Hepatology. 2009;49:S174–S184
- . Efficacy of lamivudine therapy and factors associated with emergence of resistance in chronic hepatitis B virus infection in Japan. Intervirology. 2003;46:182–189
- Comprehensive evaluation of hepatitis B virus reverse transcriptase substitutions associated with entecavir resistance. Hepatology. 2008;47:1473–1482
- 2-Year GLOBE trial results: telbivudine is superior to lamivudine in patients with chronic hepatitis B. Gastroenterology. 2009;136:486–495
- Adefovir rapidly suppresses hepatitis B in HBeAg-negative patients developing genotypic resistance to lamivudine. Hepatology. 2005;42:1414–1449
- Efficacy of long-term lamivudine monotherapy in patients with hepatitis B e antigen-negative chronic hepatitis B. Hepatology. 2000;32:847–851
- Course of virologic breakthroughs under long-term lamivudine in HBeAg-negative precore mutant HBV liver disease. Hepatology. 2002;36:219–226
- The profile of mutational clusters associated with lamivudine resistance can be constrained by HBV genotypes. J Hepatol. 2009;50:461–470
- Viral persistence after liver transplantation for hepatitis B virus: a cross-sectional study. Transplantation. 2008;85:1105–1111
- . EASL clinical practice guidelines. J Hepatol. 2009;51:821–822
- Emergence of a novel lamivudine-resistant hepatitis B virus variant with a substitution outside the YMDD motif. Antimicrob Agents Chemother. 2006;50:3867–3874
- . The antiviral drug selected hepatitis B virus rtA181T/sW172* mutant has a dominant negative secretion defect and alters the typical profile of virological breakthrough. Hepatology. 2008;48:88–98
- Identification of nonsense mutations in hepatitis B virus S gene in patients with hepatocellular carcinoma developed after lamivudine therapy. Antivir Ther. 2009;14:249–261
- Characterization of potential antiviral resistance mutations in hepatitis B virus reverse transcriptase sequences in treatment-naïve Chinese patients. J Gastroenterol Hepatol. 2009;24:1417–1423
- Ultra-deep sequencing analysis demonstrates pre-existence of HBV resistance substitution at baseline in patients who subsequently develop clinical resistance. In: CROI. 2010;[Abst N 170lb]
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PII: S1590-8658(10)00164-7
doi: 10.1016/j.dld.2010.04.017
© 2010 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Inc All rights reserved.
« Previous
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Digestive and Liver Disease
Volume 42, Issue 12
, Pages 902-907
, December 2010
