Digestive and Liver Disease
Volume 42, Issue 8 , Pages 560-566 , August 2010

Unexplained iron deficiency anaemia: Is it worthwhile to perform capsule endoscopy?

  • Maria Elena Riccioni

      Affiliations

    • Digestive Endoscopy Unit, Catholic University of Rome, Rome, Italy
    • ,
  • Riccardo Urgesi

      Affiliations

    • Digestive Endoscopy Unit, Catholic University of Rome, Rome, Italy
    • Cattedra di Alimentazione e Nutrizione Umana, Dipartimento di Neuroscienze, Tor Vergata University, Rome, Italy
    • Corresponding Author InformationCorresponding author at: Digestive Endoscopy Unit, Catholic University of Rome, Largo A. Gemelli, 8, 00168 Rome, Italy. Tel.: +39 06 30156580; fax: +39 06 30156581.
    • ,
  • Cristiano Spada

      Affiliations

    • Digestive Endoscopy Unit, Catholic University of Rome, Rome, Italy
    • ,
  • Rossella Cianci

      Affiliations

    • Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
    • ,
  • Giorgio Pelecca

      Affiliations

    • Gastroenterology Unit, Viterbo, Italy
    • ,
  • Alessandra Bizzotto

      Affiliations

    • Digestive Endoscopy Unit, Catholic University of Rome, Rome, Italy
    • ,
  • Guido Costamagna

      Affiliations

    • Digestive Endoscopy Unit, Catholic University of Rome, Rome, Italy

Received 17 November 2009 ,Accepted 29 January 2010.

References 

  1. Brittenham GM. Disorders of iron metabolism: deficiency and overload. In:  Hoffman R,  Benz EJ,  Shattil SJ,  Furie B,  Cohen HJ,  Silberstein LE editor. Hematology: basic principles and practice. New York: Churchill Livingstone; 1995;p. 492–523
  2. Looker AC, Dallman PR, Carroll MD, et al. Prevalence of iron deficiency in the United States. J Am Med Assoc. 1997;277:973–976
  3. Zuckerman GR, Prakash C, Askin MP, et al. AGA technical review on the evaluation and management of occult and obscure gastrointestinal bleeding. Gastroenterology. 2000;18:201–221
  4. Rockey DC, Cello JP. Evaluation of the gastrointestinal tract in patients with iron-deficiency anaemia. N Engl J Med. 1993;329:1691–1695
  5. Moch A, Herlinger H, Kochman ML, et al. Enteroclysis in the evaluation of obscure gastrointestinal bleeding. Am J Roentgenol. 1994;163:1381–1384
  6. Chak A, Cooper GS, Canto MI, et al. Enteroscopy for the initial evaluation of iron deficiency. Gastrointest Endosc. 1998;47:144–148
  7. Marmo R, Rotondano G, Piscopo R, et al. Meta-analysis: capsule enteroscopy vs. conventional modalities in diagnosis of small bowel diseases. Aliment Pharmacol Ther. 2005;22:595–604
  8. Pennazio M, Eisen G, Goldfarb N. ICCE consensus for obscure gastrointestinal bleeding. Endoscopy. 2005;37:1046–1050
  9. Fireman Z, Kopelman Y. The role of video capsule endoscopy in the evaluation of iron deficiency anaemia. Dig Liver Dis. 2004;36:97–102
  10. Ell C, May A. Mid-gastrointestinal bleeding: capsule endoscopy and push-and-pull enteroscopy give rise to a new medical term. Endoscopy. 2006;38:73–75
  11. Apostolopoulos P, Liatsos C, Gralnek IM, et al. The role of wireless capsule endoscopy in investigating unexplained iron deficiency anemia after negative endoscopic evaluation of the upper and lower gastrointestinal tract. Endoscopy. 2006;38:1127–1132
  12. Mishkin DS, Chuttani R, Croffie J, et al. ASGE technology status evaluation report: WCE. Gastrointest Endosc. 2006;63:539–545
  13. Rockey DC. Gastrointestinal bleeding. In: 7th ed..  Feldeman M,  Friedman LS,  Sleisneger MH editor. Gastrointestinal and liver disease. vol. 1:Philadelphia: Saunders; 2002;p. 221–248
  14. Nolan DJ, Traill ZC. The current role of the barium examination of the small intestine. Clin Radiol. 1997;52:809–820
  15. Goddard AF, McIntyre AS, Scott BB. Guidelines for the management of iron deficiency anemia for the British Society of Gastroenterology. Gut. 2000;46(Suppl. 4):1–5
  16. Swain CP. The role of enteroscopy in clinical practice. Gastrointest Endosc Clin N Am. 1999;9:135–144
  17. Landi B, Tkoub M, Gaudric M, et al. Diagnostic yield of push-type enteroscopy in relation to indication. Gut. 1998;42:421–424
  18. Chak A, Cooper GS, Canto MI, et al. Enteroscopy for the initial evaluation of iron deficiency. Gastrointest Endosc. 1998;47:144–148
  19. Matsumoto T, Esaki M, Moriyam T, et al. Comparison of capsule endoscopy and enteroscopy with the double-balloon method in patients with obscure bleeding and polyposis. Endoscopy. 2005;37:827–832
  20. Gurudu SR, Fleischer DE. From small-bowel bleeding to anemia: a wider range of indications for the capsule endoscope?. Endoscopy. 2006;38:1144–1145
  21. Brown C, Olshaker J. Meckel's diverticulum. Am J Emerg Med. 1988;6:157–164
  22. Markisz J, Front D, Royal H. An evaluation of 99m-Tc labeled red blood cell scintigraphy for the detection and localization of gastrointestinal bleeding sites. Gastroenterology. 1982;83:394–398
  23. Rollins ES, Picus D, Hicks ME, et al. Angiography is useful in detecting the source of chronic gastrointestinal bleeding of obscure origin. Am J Roentgenol. 1991;156:385–389
  24. Ettorre G, Francioso G, Garribba A. Helical CT angiography in gastrointestinal bleeding of obscure origin. Am J Radiol Roentgenol. 1997;168:727–730
  25. Costamagna G, Shah SK, Riccioni ME, et al. A prospective trial comparing small bowel radiographs and video capsule endoscopy for suspected small bowel disease. Gastroenterology. 2002;123:1385–1388
  26. Triester SL, Leighton JA, Leontiadis GI, et al. A meta-analysis of the yield of capsule endoscopy compared to other diagnostic modalities in patients with obscure GI bleeding. Am J Gastroenterol. 2005;100:2407–2418
  27. Scapa E, Jacob H, Lewkowic S, et al. Results of the first clinical studies performed in Israel with wireless capsule endoscopy. Am J Gastroenterol. 2002;97:2776–2779
  28. Lewis BS, Swain P. Capsule endoscopy in the evaluation of patients with suspected small intestinal bleeding results of a pilot study. Gastrointest Endosc. 2002;349–353
  29. Saurin JC, Delavaux M, Gauin JL, et al. Diagnostic value of endoscopic capsule in patients with obscure digestive bleeding: blinded comparison with push-enteroscopy. Endoscopy. 2003;35:576–584
  30. Pennazio M, Santucci R, Rondonotti E, et al. Wireless capsule endoscopy in patients with obscure gastrointestinal bleeding: results of the Italian multicentre experience. Gastrointest Endosc. 2002;55:pAB87
  31. Carey EJ, Leighton JA, Heigh RI, et al. A single-center experience of 260 consecutive patients undergoing capsule endoscopy for obscure gastrointestinal bleeding. Am J Gastroenterol. 2007;102:89–95
  32. Muhammad A, Pitchumoni CS. Evaluation of iron deficiency anemia in older adults: the role of wireless capsule endoscopy. J Clin Gastroenterol. 2009;43:627–631
  33. Sheibani S, Levesque BG, Friedland S, et al. Long-term impact of capsule endoscopy in patients referred for iron-deficiency anemia. Dig Dis Sci. 2009;[Epub ahead of print]

PII: S1590-8658(10)00049-6

doi: 10.1016/j.dld.2010.01.023

Digestive and Liver Disease
Volume 42, Issue 8 , Pages 560-566 , August 2010

Article Tools

* Image Usage & Resolution