Digestive and Liver Disease
Volume 42, Issue 4 , Pages 283-284 , April 2010

Maintenance ribavirin monotherapy: The case for post-transplantation recurrent hepatitis C

  • Christian Trepo

      Affiliations

    • Department of Hepatogastroenterology, Hospices Civils de Lyon Hopital Hotel Dieu, 69002 Lyon, France
    • Unité de recherche sur les hépatites virales, INSERM U 871, Lyon, France
    • Lyon University 69003 Lyon, France
    • Corresponding Author InformationCorresponding author at: Service Hepatogastroenterology, Hopital Hotel Dieu, 69288 Lyon Cedex 02, France. Tel.: +33 4 72 68 19 70/72; fax: +33 4 72 68 19 71.
    • ,
  • Francois Bailly

      Affiliations

    • Department of Hepatogastroenterology, Hospices Civils de Lyon Hopital Hotel Dieu, 69002 Lyon, France
    • Unité de recherche sur les hépatites virales, INSERM U 871, Lyon, France
    • Lyon University 69003 Lyon, France

References 

  1. Lionetti R, Tisone G, Palmieri G, et al. Maintenance ribavirin monotherapy delays fibrosis progression in liver transplant recipients with recurrent hepatitis C at high risk of progression. Digest Liver Dis. 2010;42:297–303
  2. Bizollon T, Ahmed SN, Radenne S, et al. Long-term histological improvement and clearance of intrahepatic hepatitis C virus RNA following sustained virological response to interferon–ribavirin combination therapy in liver transplanted patients with hepatitis C virus recurrence. Gut. 2003;52:283–287
  3. Bodenheimer HC, Lindsay KL, Davis GL, et al. Tolerance and efficacy of oral ribavirin treatment of chronic hepatitis C: a multicenter trial. Hepatology. 1997;26:473–477
  4. Hoofnagle JH, Ghany MG, Kleiner DE, et al. Maintenance therapy with ribavirin in patients with chronic hepatitis C who fail to respond to combination therapy with interferon alfa and ribavirin. Hepatology. 2003;38:66–74
  5. Trepo C, Bonaventure C, Calay V, et al. Long-term maintenance ribavirin monotherapy in chronic hepatitis C patients not responding or intolerant to interferon alpha. J Clin Virol. 2006;36:S39
  6. Brok J, Gluud LL, Gluud C. Ribavirin monotherapy for chronic hepatitis C infection: a cochrane hepato-biliary group systematic review and meta-analysis of randomized trial. Am J Gastroenterol. 2006;101:842–847
  7. Maynard M, Pradat P, Gagnieu MC, et al. Prediction of sustained virological response by ribavirin plasma concentration at week 4 of therapy in hepatitis C virus genotype 1 patients. Antivir Ther. 2008;13:607–611
  8. Töx U, Hendi B, Groeser T, et al. Ribavirin priming in patients with chronic hepatitis C and normal ALT: a pilot study. Hepatogastroenterology. 2008;55:1666–1670

PII: S1590-8658(10)00046-0

doi: 10.1016/j.dld.2010.02.001

Digestive and Liver Disease
Volume 42, Issue 4 , Pages 283-284 , April 2010

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