Digestive and Liver Disease
Volume 42, Issue 6 , Pages 390-400, June 2010

Update on primary sclerosing cholangitis

Norwegian PSC Research Center, Medical Department, Oslo University Hospital, Rikshospitalet, Oslo, Norway

Received 17 December 2009; accepted 17 January 2010. published online 22 February 2010.

Abstract 

Early studies in primary sclerosing cholangitis (PSC) were concerned with disease characterization, and were followed by epidemiological studies of PSC and clinical subsets of PSC as well as a large number of treatment trials. Recently, the molecular pathogenesis and the practical handling of the patients have received increasing attention. In the present review we aim to give an update on the pathogenesis of PSC and cholangiocarcinoma in PSC, as well as to discuss the current opinion on diagnosis and treatment of PSC in light of the recent European Association for the Study of the Liver and the American Association for the Study of Liver Diseases practice guidelines.

Keywords: Cholangiocarcinoma, HLA genes, Inflammatory bowel disease, Primary sclerosing cholangitis

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PII: S1590-8658(10)00015-0

doi:10.1016/j.dld.2010.01.011

Digestive and Liver Disease
Volume 42, Issue 6 , Pages 390-400, June 2010

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