Digestive and Liver Disease
Volume 42, Issue 8 , Pages 544-548 , August 2010

Altered mRNA expression of telomere binding proteins (TPP1, POT1, RAP1, TRF1 and TRF2) in ulcerative colitis and Crohn's disease

  • Nancy Da-Silva

      Affiliations

    • Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Clifford Bridge Rd, Coventry, CV2 2DX, UK
  • ,
  • Ramesh Arasaradnam

      Affiliations

    • Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Clifford Bridge Rd, Coventry, CV2 2DX, UK
    • University Hospital of Coventry, Clifford Bridge Rd, Coventry, CV2 2DX, UK
  • ,
  • Katherine Getliffe

      Affiliations

    • Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Clifford Bridge Rd, Coventry, CV2 2DX, UK
  • ,
  • Edward Sung

      Affiliations

    • University Hospital of Coventry, Clifford Bridge Rd, Coventry, CV2 2DX, UK
  • ,
  • Ye Oo

      Affiliations

    • University Hospital of Coventry, Clifford Bridge Rd, Coventry, CV2 2DX, UK
  • ,
  • Chuka Nwokolo

      Affiliations

    • University Hospital of Coventry, Clifford Bridge Rd, Coventry, CV2 2DX, UK
    • Corresponding Author InformationCorresponding author. Tel.: +44 02476 966087; fax: +44 02476 966090.

Received 7 May 2009 ,Accepted 13 December 2009.

References 

  1. Bouma G, Strober W. The immunological and genetic basis of inflammatory bowel disease. Nat Rev Immunol. 2003;3:521–533
  2. Ekbom A, Helmick C, Zack M, et al. Ulcerative colitis and colorectal cancer. A population-based study. N Engl J Med. 1990;323:1228–1233
  3. Loeb KR, Loeb LA. Genetic instability and the mutator phenotype. Studies in ulcerative colitis. Am J Pathol. 1999;154:1621–1626
  4. O'Sullivan JN, Bronner MP, Brentnall TA, et al. Chromosomal instability in ulcerative colitis is related to telomere shortening. Nat Genet. 2002;32:280–284
  5. Cottliar A, Fundia A, Boerr L, et al. High frequencies of telomeric associations, chromosome aberrations, and sister chromatid exchanges in ulcerative colitis. Am J Gastroenterol. 2000;95:2301–2307
  6. Bonassi S, Abbondandolo A, Camurri L, et al. Are chromosome aberrations in circulating mononuclears predictive of future cancer onset in humans? Preliminary results of an Italian cohort study. Cancer Genet Cytogenet. 1995;79:133–135
  7. Blackburn EH. Switching, and signalling at the telomere. Cell. 2001;106:661–673
  8. de Lange T. Protection of mammalian telomeres. Oncogene. 2002;21:532–540
  9. Karlseder J. Telomere repeat binding factors: keeping the ends in check. Cancer Lett. 2003;194:189–197
  10. Lee HW, Blasco MA, Gottlieb GJ, et al. Essential role of mouse telomerase in highly proliferative organs. Nature. 1998;392:569–574
  11. Getliffe KM, Al Dulaimi D, Martin-Ruiz C, et al. Mononuclear telomere dynamics and telomerase activity in inflammatory bowel disease: effect of drugs and smoking. Aliment Pharmacol Ther. 2005;21:121–131
  12. de Lange T. Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev. 2005;19:2100–2110
  13. Stansel RM, de Lange T, Griffith JD. T-loop assembly in vitro involves binding of TRF2 near the 3′ telomeric overhang. Embo J. 2001;20:5532–5540
  14. van Steensel B, Smogorzewska A, de Lange T. TRF2 protects human telomeres from end-to-end fusions. Cell. 1998;92:401–413
  15. Bradshaw PS, Stavropoulos DJ, Meyn MS. Human telomeric protein TRF2 associates with genomic double-strand breaks as an early response to DNA damage. Nat Genet. 2005;37:193–197
  16. Dantzer F, Giraud-Panis MJ, Jaco I, et al. Functional interaction between poly(ADP-ribose) polymerase 2 (PARP-2) and TRF2: PARP activity negatively regulates TRF2. Mol Cell Biol. 2004;24:1595–1607
  17. Fotiadou P, Henegariu O, Sweasy JB. DNA polymerase beta interacts with TRF2 and induces telomere dysfunction in a murine mammary cell line. Cancer Res. 2004;64:3830–3837
  18. Harvey RF, Bradshaw JM. A simple index of Crohn's-disease activity. Lancet. 1980;1:514
  19. Freshney R. Culture of animal cells: a manual of basic technique. New York: Alan R. Liss, Inc.; 1987;p. 117
  20. Yamada K, Yagihashi A, Yamada M, et al. Decreased gene expression for telomeric-repeat binding factors and TIN2 in malignant hematopoietic cells. Anticancer Res. 2002;22:1315–1320
  21. Rabinovitch PS, Dziadon S, Brentnall TA, et al. Pancolonic chromosomal instability precedes dysplasia and cancer in ulcerative colitis. Cancer Res. 1999;59:5148–5153
  22. Askling J, Brandt L, Lapidus A, et al. Risk of haematopoietic cancer in patients with inflammatory bowel disease. Gut. 2005;54:617–622
  23. Johnstone AP, Williams GT. Role of DNA breaks and ADP-ribosyl transferase activity in eukaryotic differentiation demonstrated in human mononuclears. Nature. 1982;300:368–370
  24. Boerrigter ME, Vijg J. Single-strand break disappearance in quiescent and phytohaemagglutinin-stimulated human peripheral blood mononuclears exposed to a single low dose of gamma-radiation. Int J Radiat Biol. 1992;61:95–101
  25. O’Connor M, Safari A, Xin H, et al. A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly. PNAS. 2006;103:11874–11879
  26. Risques RA, Lai LA, Brentall TA, et al. Ulcerative Colitis is a disease of accelerated colon ageing: evidence of from telomere attrition and DNA damage. Gastroenterology. 2008;135:410–418
  27. Arasaradnam RP, Khoo KT, Bardburn M, et al. Telomere attrition in colorectal mucosa of patients with ulcerative colitis (abs). Gut. 2009;A100–257
  28. Colgin L, Reddel R, Telomere Biology: . A new player in the End Zone. Curr Biol. 2004;14:901–902
  29. Rubin DT, LoSavio A, Yadron N, et al. Aminosalicylate therapy in the prevention of dysplasia and colorectal cancer in ulcerative colitis. Clin Gastroenterol Hepatol. 2006;4:1346–1350

PII: S1590-8658(09)00472-1

doi: 10.1016/j.dld.2009.12.005

Digestive and Liver Disease
Volume 42, Issue 8 , Pages 544-548 , August 2010