Digestive and Liver Disease
Volume 42, Issue 6 , Pages 425-427 , June 2010

HLA-DQ2 and -DQ8 genotypes in celiac and healthy Libyan children

  • Kamla Alarida

      Affiliations

    • Department of Pediatrics, “Omar Al Mukhtar” University, Al Bayda, Libya
    • ,
  • Jumma Harown

      Affiliations

    • El Thoura Hospital, Al Bayda, Libya
    • ,
  • Maria Rosaria Di Pierro

      Affiliations

    • Biodiagene S.r.L., Palermo, Italy
    • ,
  • Sandro Drago

      Affiliations

    • Biodiagene S.r.L., Palermo, Italy
    • ,
  • Carlo Catassi

      Affiliations

    • Department of Pediatrics, Università Politecnica delle Marche, Ancona, Italy
    • Center For Celiac Research, University of Maryland School of Medicine, Baltimore, USA
    • Corresponding Author InformationCorresponding author at: Department of Pediatrics, Università Politecnica delle Marche, Via Corridoni 11, 60123 Ancona, Italy. Tel.: +39 071 5962364; fax: +39 071 36281.

Received 4 May 2009 ,Accepted 11 September 2009.

References 

  1. Fasano A, Catassi C. Current approaches to diagnosis and treatment of celiac disease: an evolving spectrum. Gastroenterology. 2001;120:636–651
  2. Wolters VM, Wijmenga C. Genetic background of celiac disease and its clinical implications. Am J Gastroenterol. 2008;103:190–195
  3. Sollid LM, Lie BA. Celiac disease genetics: current concepts and practical applications. Clin Gastroenterol Hepatol. 2005;3:843–851
  4. Karell K, Louka AS, Moodie SJ, et al. HLA types in celiac disease patients not carrying the DQA1*05-DQB1*02 (DQ2) heterodimer: results from the European Genetic Cluster on Coeliac Disease. Hum Immunol. 2003;64:469–477
  5. Karinen H, Karkkainen P, Pihlajamaki J, et al. Gene dose effect of the DQB1*0201 allele contributes to severity of coeliac disease. Scand J Gastroenterol. 2006;41:191–199
  6. Murray JA, Moore SB, Van Dyke CT, et al. HLA DQ gene dosage and risk and severity of celiac disease. Clin Gastroenterol Hepatol. 2007;5:1406–1412
  7. Catassi C, Yachha SK. The global village of celiac disease. In:  Fasano A,  Troncone R,  Branski D editor. Frontiers in coeliac disease. Pediatr adolesc med. vol. 12:Basel: Karger; 2008;p. 23–31
  8. Catassi C, Rätsch IM, Gandolfi L, et al. Why is coeliac disease endemic in the people of Sahara?. Lancet. 1999;354:647–648
  9. Catassi C, Doloretta Macis M, Rätsch IM, et al. The distribution of HLA-DQ genes in the Saharawi population provides only a partial explanation for the high celiac disease prevalence. Tissue Antigens. 2001;58:402–406
  10. Bouguerra F, Babron MC, Eliaou JF, et al. Synergistic effect of two heterodimers in the susceptibility to celiac disease in Tunisia. Genet Epidemiol. 1997;14:413–422
  11. Megiorni F, Mora B, Bonamico M, et al. HLA-DQ and risk gradient for celiac disease. Hum Immunol. 2009;70:55–59
  12. Ben Hariz M, Kallel-Sellami M, Kallel L, et al. Prevalence of celiac disease in Tunisia: mass screening study in school children. Eur J Gastroenterol Hepatol. 2007;19:687–694
  13. Abu-Zekry M, Kryszak D, Diab M, et al. Prevalence of celiac disease in Egyptian children disputes the East-West agriculture-dependent spread of the disease. J Pediatr Gastroenterol Nutr. 2008;47:136–140
  14. Data available at: http://faostat.fao.org.
  15. Pociot F, McDermott MF. Genetics of type 1 diabetes mellitus. Genes Immun. 2002;3:235–249
  16. Kadiki OA, Roaeid RB. Incidence of type 1 diabetes in children (0–14 years) in Benghazi Libya (1991–2000). Diabetes Metab. 2002;28:463–467

PII: S1590-8658(09)00372-7

doi: 10.1016/j.dld.2009.09.004

Digestive and Liver Disease
Volume 42, Issue 6 , Pages 425-427 , June 2010

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