Digestive and Liver Disease
Volume 38, Supplement 2 , Pages S261-S265, December 2006

Antibiotic resistance: the pros and cons of probiotics

  • Patrice Courvalin

      Affiliations

    • Corresponding Author InformationUnité des Agents Antibactériens, Institut Pasteur, 25-28 rue du Docteur Roux, 75724 Paris Cedex 15, France. Tel.: +33 1 45 63 83 20; fax: +33145688319

Unité des Agents Antibactériens, Institut Pasteur, 25-28 rue du Docteur Roux, 75724 Paris Cedex 15, France

Abstract 

For the prevention of intestinal disorders, probiotics can be rendered multidrug resistant to survive in the presence of co-administered antibiotics. This generates the possibility of resistance transfer from the probiotic to human bacterial pathogens, either directly or indirectly via the commensal flora. This article reviews the experiments to be performed and the criteria for assessment of safety of antibiotic resistant probiotics.

Keywords:  Probiotics , Antibiotic , Gene transfer , Intrinsic resistance , Acquired resistance

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PII: S1590-8658(07)60006-1

doi:10.1016/S1590-8658(07)60006-1

Digestive and Liver Disease
Volume 38, Supplement 2 , Pages S261-S265, December 2006

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